The multiple roles of monocyte subsets in steady state and inflammation

被引：102

作者：

Robbins, Clinton S. ^{[1
]}

Swirski, Filip K. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2010年 / 67卷 / 16期

关键词：

Monocyte subsets; Inflammation; Hematopoietic system; Macrophage; Dendritic cell; PERIPHERAL LYMPHOID ORGANS; ATHEROSCLEROTIC LESION FORMATION; T-CELL-ACTIVATION; DENDRITIC CELLS; BLOOD MONOCYTES; BONE-MARROW; MYD88-DEPENDENT ACTIVATION; CD14(+)CD16(+) MONOCYTES; LISTERIA-MONOCYTOGENES; LY-6C(HI) MONOCYTES;

D O I：

10.1007/s00018-010-0375-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in blood or reside in a spleen reservoir before entering tissue and giving rise to macrophages or dendritic cells. Monocytes are more than transitional cells that adapt to a particular tissue environment indiscriminately. Accumulating evidence now indicates that monocytes are heterogeneous in several species and are themselves predetermined for particular function in the steady state and inflammation. Future therapeutics may harness this heterogeneity to target harmful functions while sparing those that are beneficial. Here, we review recent advances on the ontogeny and function of monocytes and their subsets in humans and mice.

引用

页码：2685 / 2693

页数：9

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