The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns

被引：28
|
作者：
Hein, Daniel [1 ]
Dreisig, Karin [2 ,3 ]
Metzler, Markus [4 ]
Izraeli, Shai [5 ,6 ]
Schmiegelow, Kjeld [2 ,3 ]
Borkhardt, Arndt [1 ]
Fischer, Ute [1 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Univ Childrens Hosp, Fac Med, Dept Pediat Oncol Hematol & Clin Immunol, Dusseldorf, Germany
[2] Copenhagen Univ Hosp, Rigshosp, Juliane Marie Ctr, Dept Pediat & Adolescent Med, Copenhagen, Denmark
[3] Univ Copenhagen, Copenhagen, Denmark
[4] Univ Hosp Erlangen, Dept Pediat, Erlangen, Germany
[5] Schneider Childrens Med Ctr Israel, Rina Zaizov Pediat Hematol Oncol Div, Petah Tiqwa, Israel
[6] Tel Aviv Univ, Sackler Sch Med, Dora & Gregorio Chair Hematol Malignancies Dept H, Tel Aviv, Israel
来源：
BLOOD | 2019年 / 134卷 / 16期
关键词：
ACUTE LYMPHOBLASTIC-LEUKEMIA; INFANT TWINS; E2A-PBX1; TRANSLOCATIONS; IDENTIFICATION; REARRANGEMENTS; ETV6-RUNX1; MLL;
D O I：
10.1182/blood.2019002215
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1355 / 1358
页数：5
相关论文
共 18 条
  • [1] B-lymphoblastic lymphoma with TCF3-PBX1 fusion gene
    Kubota-Tanaka, Mari
    Osumi, Tomoo
    Miura, Shouko
    Tsujimoto, Hiroshi
    Imamura, Toshihiko
    Nishimura, Akira
    Oki, Kentaro
    Nakamura, Kozue
    Miyamoto, Satoshi
    Inoue, Kento
    Inoue, Maiko
    Kamiya, Takahiro
    Yanagimachi, Masakatsu
    Okano, Tsubasa
    Mitsuiki, Noriko
    Isoda, Takeshi
    Imai, Kohsuke
    Kanegane, Hirokazu
    Morio, Tomohiro
    Kounami, Shinji
    Endo, Mikiya
    Kato, Motohiro
    Takagi, Masatoshi
    HAEMATOLOGICA, 2019, 104 (01) : E35 - E37
  • [2] HIGH FREQUENCY OF TCF3-PBX1 FUSION GENE AMONG IRAQI PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA: A STUDY IN JAPAN
    Al-Kzayer, Lika'A
    Okuno, Yusuke
    Al-Jadiry, Mazin
    Al-Hadad, Salma
    Al-Saeed, Raghad
    Nakazawa, Yozo
    PEDIATRIC BLOOD & CANCER, 2023, 70
  • [3] Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience
    Malhotra, Payal
    Jain, Sandeep
    Agarwal, Arushi
    Sharma, Anurag
    Agarwal, Narender
    Kapoor, Gauri
    INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2022, 38 (01) : 164 - 168
  • [4] Incidence and Prognostic Impact of TCF3-PBX1 Fusion in Childhood Acute Lymphoblastic Leukemia: A Single Centre Experience
    Payal Malhotra
    Sandeep Jain
    Arushi Agarwal
    Anurag Sharma
    Narender Agarwal
    Gauri Kapoor
    Indian Journal of Hematology and Blood Transfusion, 2022, 38 : 164 - 168
  • [5] Determination of the Origin of the t(1;19) TCF3-PBX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)
    Hein, Daniel
    Dreisig, Karin
    Izraeli, Shai
    Schmiegelow, Kjeld
    Borkhardt, Arndt
    Fischer, Ute
    BLOOD, 2018, 132
  • [6] Clinical Features and Prognostic Significance of TCF3-PBX1 Fusion Gene in Chinese Children with Acute Lymphoblastic Leukemia by Using a Modified ALL-BFM-95 Protocol
    Pang, Li
    Liang, Ying
    Pan, Jian
    Wang, Jian-Rong
    Chai, Yi-Huan
    Zhao, Wen-Li
    PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2015, 32 (03) : 173 - 181
  • [7] Acute Lymphoblastic Leukemia with t(1;19)(q23;p13)/TCF3-PBX1 Fusion in an Adult Male with Down Syndrome
    Yamamoto, Shohei
    Ebihara, Yasuhiro
    Mochizuki, Shinji
    Tsuda, Mayuko
    Yuji, Koichiro
    Uchimaru, Kaoru
    Tojo, Arinobu
    Tsuji, Kohichiro
    ACTA HAEMATOLOGICA, 2012, 128 (04) : 242 - 243
  • [8] A (1;19) translocation involving TCF3-PBX1 fusion within the context of a hyperdiploid karyotype in adult B-ALL: A case report and review of the literature
    Tirado C.A.
    Shabsovich D.
    Yeh L.
    Pullarkat S.T.
    Yang L.
    Kallen M.
    Rao N.
    Biomarker Research, 3 (1)
  • [9] Co-occurrence of TCF3-PBX1 gene fusion, and chromosomal aberration in a pediatric pre-B cell acute lymphoblastic leukemia with clitoris swelling A case report and literature review
    He, Guo-qian
    Guo, Xia
    Jiang, Ming-yan
    Xu, Rong-rong
    Dai, Yi-ling
    Luo, Lili
    Gao, Ju
    MEDICINE, 2021, 100 (08) : E24802
  • [10] 18F-FDG PET/CT for the detection of extensive bone relapse in acute lymphoblastic leukemia with TCF3-PBX1 fusion after hematopoietic stem cell transplantation
    Wang, Xiaoning
    Niu, Fan
    Ren, Juan
    He, Pengcheng
    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2022, 12 (07) : 4002 - 4004
12