Non-invasive tools for the diagnosis of cutaneous melanoma

被引:58
|
作者
Fink, C. [1 ]
Haenssle, H. A. [1 ]
机构
[1] Heidelberg Univ, Dept Dermatol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany
关键词
melanoma; atypical nevus; dysplastic nevus; diagnostic devices; dermoscopy; sequential digital dermoscopy; total body photography; reflectance confocal microscopy; computer-aided multispectral digital analysis; electrical impedance spectroscopy; Raman spectroscopy; in vivo multiphoton tomography; stepwise two-photon-laser spectroscopy; infrared thermal image analysis; MELANOCYTIC SKIN-LESIONS; ELECTRICAL-IMPEDANCE SPECTROSCOPY; LASER-SCANNING MICROSCOPY; TOTAL-BODY PHOTOGRAPHY; NAKED-EYE EXAMINATION; IN-VIVO; EPILUMINESCENCE MICROSCOPY; MALIGNANT-MELANOMA; FOLLOW-UP; HIGH-RISK;
D O I
10.1111/srt.12350
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: While the excisional biopsy and histological examination of suspicious lesions remains the current gold standard for diagnosing cutaneous melanoma (CM), there is a demand for more objective and non-invasive examination methods that may support clinicians in their decision when to biopsy or not. Methods: This review is based on publications and guidelines retrieved by a selective search in PubMed and MEDLINE and focused on non-invasive diagnostic strategies for detecting melanoma. Results: Ten different non-invasive techniques were compared with regard to applicability, status of development, and resources necessary for introduction into clinical routine (dermoscopy, sequential digital dermoscopy, total body photography, computer-aided multispectral digital analysis, electrical impedance spectroscopy, Raman spectroscopy, reflectance confocal microscopy, multiphoton tomography, stepwise two-photon-laser spectroscopy, quantitative dynamic infrared imaging). In an effort to create a classification based on our analyses, we suggest to differentiate i) tools for screening of patients in daily clinical routine, ii) tools for examination of a restricted number of preselected lesions that produce an automated diagnostic score, iii) tools for examination of a restricted number of preselected lesions at specialized centers requiring extensive training, iv) devices at an experimental stage of development. Conclusion: None of the discussed examination techniques is able to provide a definite and final diagnosis or to completely replace the histopathological examination. Up to date, the need for fully automated devices offering a complete skin cancer screening has not been satisfied.
引用
收藏
页码:261 / 271
页数:11
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