Nickel-catalyzed Suzuki-Miyaura cross-coupling of C-F bonds

被引：14
|
作者：
Zhang, Tianhao [1 ]
Nohira, Itsuki [1 ]
Chatani, Naoto [1 ]
机构：
[1] Osaka Univ, Fac Engn, Dept Appl Chemisuy, Suita, Osaka 5650871, Japan
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 14期
关键词：
METHYL ETHERS; PALLADIUM; ARYL; ACTIVATION; ESTERS;
D O I：
10.1039/d1qo00656h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The efficient Suzuki-Miyaura cross-coupling of ortho-fluoro aromatic secondary amides with aryl boronates is described. The use of (KOBu)-Bu-t is essential for the reaction to proceed. The function of the base is to abstract a proton from an amide nitrogen to generate a weak conjugate base, such as an amidate, which functions as a directing group. The reaction proceeds effectively, even at 60 degrees C. The reaction exhibits a good tolerance for functional groups and a broad scope for aromatic amides.
引用
收藏
页码：3783 / 3787
页数：5
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