Efficacy and safety of 24 weeks treatment with oral TLR8 agonist, selgantolimod, in virally-suppressed adult patients with chronic hepatitis B: a phase 2 study

被引：0
|
作者：
Gane, Edward [1 ]
Dunbar, P. Rod [2 ,3 ]
Brooks, Anna [2 ,3 ]
Zhao, Yang [4 ]
Tan, Susanna [4 ]
Lau, Audrey [4 ]
Yang, Jenny [4 ]
Gaggar, Anuj [4 ]
Subramanian, Mani [4 ]
Kottilil, Shyamasundaran [5 ]
Tang, Lydia [5 ]
机构：
[1] Auckland City Hosp, Auckland, New Zealand
[2] Univ Auckland, Sch Biol Sci, Auckland, New Zealand
[3] Univ Auckland, Maurice Wilkins Ctr, Auckland, New Zealand
[4] Gilead Sci Inc, Foster City, CA USA
[5] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA
来源：
JOURNAL OF HEPATOLOGY | 2020年 / 73卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AS071
引用
收藏
页码：S52 / S52
页数：1
相关论文
共 50 条
  • [1] SAFETY AND EFFICACY OF 24 WEEKS TREATMENT WITH ORAL TLR8 AGONIST, SELGANTOLIMOD, IN VIREMIC ADULT PATIENTS WITH CHRONIC HEPATITIS B: A PHASE 2 STUDY
    Janssen, Harry L. A.
    Lim, Young-Suk
    Kim, Hyung Joon
    Tseng, Cheng-Hao
    Coffin, Carla S.
    Elkhashab, Magdy
    Ahn, Sang Hoon
    Nguyen, Anh-Hoa
    Chen, Diana
    Wallin, Jeffrey
    Tan, Susanna
    Yang, Jenny C.
    Gagger, Anuj
    Brainard, Diana M.
    Fung, Scott K.
    Kim, Yoon Jun
    Kao, Jia-Horng
    Chuang, Wan-Long
    [J]. HEPATOLOGY, 2020, 72 : 506A - 507A
  • [2] Safety and Efficacy of Oral TLR8 Agonist, Selgantolimod, in Viremic Adult Patients With Chronic Hepatitis B
    Janssen, Harry
    Lim, Young-Suk
    Kim, Hyung Joon
    Tseng, Cheng-Hao
    Coffin, Carla
    Elkashab, Magdy
    Ahn, Sang Hoon
    Nguyen, Anh-Hoa
    Chen, Diana
    Wallin, Jeffrey
    Tan, Susana
    Yang, Jenny
    Gaggar, Anuj
    Brainard, Diana
    Fung, Scott
    Kim, Yoon Jun
    Kao, Jia-Horng
    Chuang, Wan-Long
    Brooks, Anna
    Dunbar, Rod
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2022, 117 (10): : S865 - S865
  • [3] Safety and efficacy of oral TLR8 agonist, selgantolimod, in viremic adult patients with chronic hepatitis B
    Janssen, Harry L. A.
    Lim, Young-Suk
    Kim, Hyung Joon
    Tseng, Cheng-Hao
    Coffin, Carla S.
    Elkashab, Magdy
    Ahn, Sang Hoon
    Anh-Hoa Nguyen
    Chen, Diana
    Wallin, Jeffrey
    Tan, Susanna
    Yang, Jenny
    Gaggar, Anuj
    Brainard, Diana
    Fung, Scott
    Kim, Yoon Jun
    Kao, Jia-Horng
    Chuang, Wan-Long
    Brooks, Anna
    Dunbar, P. Rod
    [J]. JOURNAL OF HEPATOLOGY, 2021, 75 : S757 - S758
  • [4] Safety, Pharmacokinetics, and Pharmacodynamics of the Oral TLR8 Agonist Selgantolimod in Chronic Hepatitis B
    Gane, Edward J.
    Kim, Hyung Joon
    Visvanathan, Kumar
    Kim, Yoon Jun
    Anh-Hoa Nguyen
    Wallin, Jeffrey J.
    Chen, Diana Y.
    McDonald, Circe
    Arora, Priyanka
    Tan, Susanna K.
    Gaggar, Anuj
    Roberts, Stuart K.
    Lim, Young-Suk
    [J]. HEPATOLOGY, 2021, 74 (04) : 1737 - 1749
  • [5] Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression
    Gane, Edward J.
    Dunbar, P. Rod
    Brooks, Anna E.
    Zhang, Fangqiu
    Chen, Diana
    Wallin, Jeffrey J.
    van Buuren, Nicholas
    Arora, Priyanka
    Fletcher, Simon P.
    Tan, Susanna K.
    Yang, Jenny C.
    Gaggar, Anuj
    Kottilil, Shyamasundaran
    Tang, Lydia
    [J]. JOURNAL OF HEPATOLOGY, 2023, 78 (03) : 513 - 523
  • [6] EFFICACY AND SAFETY OF ORAL TLR8 AGONIST GS-9688 IN VIRALLY-SUPPRESSED ADULT PATIENTS WITH CHRONIC HEPATITIS B: A PHASE 2, RANDOMIZED, DOUBLE-BLIND PLACEBO-CONTROLLED, MULTI-CENTER STUDY
    Gane, Edward J.
    Zhao, Yang
    Tan, Susanna
    Lau, Audrey H.
    Gaggar, Anuj
    Subramanian, Mani
    Kottilil, Shyam
    Tang, Lydia
    [J]. HEPATOLOGY, 2019, 70 : 435A - 436A
  • [7] Safety and Efficacy of GS-9620 in Virally-Suppressed Patients with Chronic Hepatitis B
    Janssen, Harry L.
    Brunetto, Maurizia R.
    Kim, Yoon Jun
    Ferrari, Carlo
    Massetto, Benedetta
    Anh-Hoa Nguyen
    Gaggar, Anuj
    Subramanian, Mani
    Yoshida, Eric M.
    Ahn, Sang Hoon
    Tsai, Naoky Cs C.
    Fung, Scott
    Gane, Edward J.
    [J]. HEPATOLOGY, 2016, 64 : 913A - 914A
  • [8] CHARACTERIZATION OF CYTOKINE RESPONSE TO TOLL RECEPTOR 8 AGONIST SELGANTOLIMOD (SLGN) IN VIREMIC AND VIRALLY SUPPRESSED CHRONIC HEPATITIS B (CHB)
    Chen, Diana
    McDonald, Circe
    Tan, Susanna
    Yang, Jenny
    Gane, Edward J.
    Janssen, Harry L. A.
    Kottilil, Shyam
    Tang, Lydia
    Coffin, Carla S.
    Ahn, Sang Hoon
    Kim, Hyung Joon
    Kim, Yoon Jun
    Lim, Young-Suk
    Chuang, Wan-Long
    Kao, Jia-Horng
    Tseng, Cheng-Hao
    Gaggar, Anuj
    Wallin, Jeffrey
    [J]. HEPATOLOGY, 2020, 72 : 437A - 438A
  • [9] Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators
    Amin, Oliver E.
    Colbeck, Emily J.
    Daffis, Stephane
    Khan, Shahzada
    Ramakrishnan, Dhivya
    Pattabiraman, Divya
    Chu, Ruth
    Steuer, Holly Micolochick
    Lehar, Sophie
    Peiser, Leanne
    Palazzo, Adam
    Frey, Christian
    Davies, Jessica
    Javanbakht, Hassan
    Rosenberg, William M. C.
    Fletcher, Simon P.
    Maini, Mala K.
    Pallett, Laura J.
    [J]. HEPATOLOGY, 2021, 74 (01) : 55 - 71
  • [10] Characterization of the intrahepatic immune response of virally- suppressed chronic hepatitis B patients to treatment with the oral TLR7 agonist GS-9620
    Boeijen, L.
    van Oord, G. W.
    Hou, J.
    van Campenhout, M. J.
    van der Heide-Mulder, M.
    Gaggar, A.
    Li, L.
    Fletcher, S. P.
    de Knegt, R. J.
    Boonstra, A.
    [J]. JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S478 - S479
12345