Sequence-selective DNA recognition: Natural products and nature's lessons

被引：196
|
作者：
Tse, WC
Boger, DL
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
CHEMISTRY & BIOLOGY | 2004年 / 11卷 / 12期
关键词：
D O I：
10.1016/j.chembiol.2003.08.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biologically active, therapeutically useful, DNA binding natural products continue to reveal new paradigms for sequence-selective recognition, to enlist beautiful mechanisms of in situ activation for DNA modification, to define new therapeutic targets, to exploit new mechanisms to achieve cellular selectivity, and to provide a rich source of new drugs. These attributes arise in compact structures of complex integrated function.
引用
收藏
页码：1607 / 1617
页数：11
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