[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Intervent Therapy, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China
Background Hepatic arterial infusion chemotherapy delivers the drug directly to the liver. We aim to explore the benefits and tolerability of Hepatic arterial infusion chemotherapy plus regorafenib in advanced colorectal liver metastasis refractory to standard systemic chemotherapy. Methods This study analyzed 47 patients treated with hepatic arterial infusion chemotherapy plus regorafenib after standard systemic oxaliplatin and/or irinotecan in combination with bevacizumab or cetuximab between Jan 2017 and Jun 2020. Regorafenib was given for only 3 weeks in a 4-week cycle. Results Among 47 patients, 32 (68%) were males. The median age was 61 (29-75). With a median follow-up of 22.2 months (3.7-50.7 months). Before Hepatic arterial infusion chemotherapy administration in combination with regorafenib, 34 (72.3%) patients previously received >= 2 prior lines of systemic therapy and 37 (78.7%)patients previously received targeted biological treatment (anti-VEGF or anti-EGFR, or both). The initial doses of regorafenib were 40 mg/d (n = 1, 2.13%), 80 mg/d (n = 11, 23.43%), 120 mg/d (n = 2, 4.26%), and 160 mg/d (n = 23, 48.94%), while for 24.6% (n = 14) dose was unknown. Median Overall Survival was 22.2 months. Median Progression-Free Survival was 10.8 (95% CI: 9.0-13.7) months. Common Adverse Events were hand-foot skin reaction (12.77%), fatigue (6.38%), vomiting (6.38%), and decreased appetite (6.38%). Only 2 patients discontinued regorafenib due to Adverse Events. Conclusions Regorafenib combined with Hepatic arterial infusion was effective and tolerable in patients with liver predominant metastasis of colorectal cancer. Hence, this therapy can be considered as an alternative for second- or subsequent lines of therapy in patients refractory to standard systemic chemotherapy.
机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Guang Cao
Xiaodong Wang
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Xiaodong Wang
Hui Chen
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Hui Chen
Song Gao
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Song Gao
Jianhai Guo
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Jianhai Guo
Peng Liu
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Peng Liu
Haifeng Xu
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Haifeng Xu
Liang Xu
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Liang Xu
Xu Zhu
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
Xu Zhu
Renjie Yang
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机构:Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Interventional Therapy
机构:
Chinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Zhao, Wenchao
Yao, Zhiyuan
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机构:
Chinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Med Sch Chinese PLA, Beijing, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Yao, Zhiyuan
Li, Jingbo
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Chinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Li, Jingbo
Li, Wenping
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Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Med Imaging, Beijing, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Li, Wenping
Dou, Qi
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Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Dept Nucl Med, Beijing, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Dou, Qi
Zhao, Xiangfei
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Chinese Peoples Liberat Army Gen Hosp, Dept Oncol, Beijing, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Zhao, Xiangfei
Wu, Yintao
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Chinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
Wu, Yintao
Xia, Nianxin
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Chinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R ChinaChinese Peoples Liberat Army Gen Hosp, Fac Hepatopancreato Biliary Surg, 6 Fucheng Rd, Beijing 100048, Peoples R China
机构:
Capital Med Univ, Beijing Chaoyang Hosp, Dept Oncol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Oncol, Beijing, Peoples R China
Yisilamu, Patiguli
Yao, Jiannan
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机构:
Capital Med Univ, Beijing Chaoyang Hosp, Dept Oncol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Oncol, Beijing, Peoples R China
Yao, Jiannan
Ge, Yang
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Capital Med Univ, Beijing Chaoyang Hosp, Dept Oncol, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Oncol, Beijing, Peoples R China