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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Natl Commiss Hlth,Key Lab Endocrinol,State Key Lab, Shuaifuyuan 1,Wangfujing St, Beijing 100730, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Natl Commiss Hlth,Key Lab Endocrinol,State Key Lab, Shuaifuyuan 1,Wangfujing St, Beijing 100730, Peoples R China