Paraoxonase-1 and Early-Life Environmental Exposures

被引:30
|
作者
Marsillach, Judit [1 ]
Costa, Lucio G. [2 ,3 ]
Furlong, Clement E. [1 ,4 ]
机构
[1] Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA
[2] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA
[3] Univ Parma, Dept Neurosci, I-43100 Parma, Italy
[4] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
来源
ANNALS OF GLOBAL HEALTH | 2016年 / 82卷 / 01期
基金
美国国家卫生研究院;
关键词
early-life exposures; environmental health; organophosphates; neurodevelopment; paraoxonase-1; HUMAN-SERUM PARAOXONASE; ORGANOPHOSPHATE PESTICIDE EXPOSURE; CHLORPYRIFOS-OXON; PON1; STATUS; GESTATIONAL EXPOSURE; MOLECULAR-BASIS; A-ESTERASE; IN-UTERO; TOXICITY; MICE;
D O I
10.1016/j.aogh.2016.01.009
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Acute and chronic exposures to widely used organophosphorus (OP) insecticides are common. Children's detoxification mechanisms are not well developed until several years after birth. The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. Paraoxonase-1 (PON1) is an enzyme that can detoxify OPs but its catalytic efficiency for hydrolysis to certain OPs is modulated by the Q192R polymorphism. Studies with animals have provided important information on the role of PON1 in protecting against gestational and postnatal toxicity to OPs. The PON1(Q192) allele is less efficient in hydrolyzing certain OPs than the PON1(R192) allele. Maternal PON1 status (PON1 activity levels, the most important measurement, and functional Q192R phenotype) modulates the detrimental effects of exposure to the OP chlorpyrifos oxon on fetal brain gene expression and biomarkers of exposure. Epidemiologic studies suggest that children from mothers with lower PON1 status who were in contact with OPs during pregnancy tend to show smaller head circumference at birth and adverse effects in cognitive function during childhood. Infants and children are vulnerable to OP toxicity. The detrimental consequences of OPs on neurodevelopment can lead to future generations with permanent cognitive problems and susceptibility to develop neurodegenerative diseases. Improved methods using mass spectrometry to monitor OP-adducted biomarker proteins are needed and will be extremely helpful in early life biomonitoring, while measurement of PON1 status as a biomarker of susceptibility will help identify mothers and children highly sensitive to OPs. The use of adductomics instead of enzymatic activity assays for biomonitoring OP exposures have proved to provide several advantages, including the use of dried blood spots, which would facilitate monitoring newborn babies and children.
引用
收藏
页码:100 / 110
页数:11
相关论文
共 50 条
  • [1] Environmental exposures in early-life and general health in childhood
    Ines Amine
    Alicia Guillien
    Claire Philippat
    Augusto Anguita-Ruiz
    Maribel Casas
    Montserrat de Castro
    Audrius Dedele
    Judith Garcia-Aymerich
    Berit Granum
    Regina Grazuleviciene
    Barbara Heude
    Line Småstuen Haug
    Jordi Julvez
    Mónica López-Vicente
    Léa Maitre
    Rosemary McEachan
    Mark Nieuwenhuijsen
    Nikos Stratakis
    Marina Vafeiadi
    John Wright
    Tiffany Yang
    Wen Lun Yuan
    Xavier Basagaña
    Rémy Slama
    Martine Vrijheid
    Valérie Siroux
    [J]. Environmental Health, 22
  • [2] Early-Life Environmental Exposures and Blood Pressure in Children
    Warembourg, Charline
    Maitre, Lea
    Tamayo-Uria, Ibon
    Fossati, Serena
    Roumeliotaki, Theano
    Aasvang, Gunn Marit
    Andrusaityte, Sandra
    Casas, Maribel
    Cequier, Enrique
    Chatzi, Lida
    Dedele, Audrius
    Gonzalez, Juan-Ramon
    Grazuleviciene, Regina
    Haug, Line Smastuen
    Hernandez-Ferrer, Carles
    Heude, Barbara
    Karachaliou, Marianna
    Krog, Norun Hjertager
    McEachan, Rosemary
    Nieuwenhuijsen, Mark
    Petraviciene, Inga
    Quentin, Joane
    Robinson, Oliver
    Sakhi, Amrit Kaur
    Slama, Remy
    Thomsen, Cathrine
    Urquiza, Jose
    Vafeiadi, Marina
    West, Jane
    Wright, John
    Vrijheid, Martine
    Basagana, Xavier
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (10) : 1317 - 1328
  • [3] Environmental exposures in early-life and general health in childhood
    Amine, Ines
    Guillien, Alicia
    Philippat, Claire
    Anguita-Ruiz, Augusto
    Casas, Maribel
    de Castro, Montserrat
    Dedele, Audrius
    Garcia-Aymerich, Judith
    Granum, Berit
    Grazuleviciene, Regina
    Heude, Barbara
    Haug, Line Smastuen
    Julvez, Jordi
    Lopez-Vicente, Monica
    Maitre, Lea
    McEachan, Rosemary
    Nieuwenhuijsen, Mark
    Stratakis, Nikos
    Vafeiadi, Marina
    Wright, John
    Yang, Tiffany
    Yuan, Wen Lun
    Basagana, Xavier
    Slama, Remy
    Vrijheid, Martine
    Siroux, Valerie
    [J]. ENVIRONMENTAL HEALTH, 2023, 22 (01)
  • [4] Select Early-Life Environmental Exposures and DNA Methylation in the Placenta
    Michael Mortillo
    Carmen J. Marsit
    [J]. Current Environmental Health Reports, 2023, 10 : 22 - 34
  • [5] The Importance of Addressing Early-Life Environmental Exposures in Cancer Epidemiology
    Niehoff, Nicole M.
    Goldberg, Mandy
    White, Alexandra J.
    [J]. CURRENT EPIDEMIOLOGY REPORTS, 2022, 9 (02) : 49 - 65
  • [6] Select Early-Life Environmental Exposures and DNA Methylation in the Placenta
    Mortillo, Michael
    Marsit, Carmen J.
    [J]. CURRENT ENVIRONMENTAL HEALTH REPORTS, 2023, 10 (01) : 22 - 34
  • [7] The Importance of Addressing Early-Life Environmental Exposures in Cancer Epidemiology
    Nicole M. Niehoff
    Mandy Goldberg
    Alexandra J. White
    [J]. Current Epidemiology Reports, 2022, 9 : 49 - 65
  • [8] Adverse early-life environmental exposures and their repercussions on adult respiratory health
    Mocelin, Helena Teresinha
    Fischer, Gilberto Bueno
    Bush, Andrew
    [J]. JORNAL DE PEDIATRIA, 2022, 98 : S86 - S95
  • [9] Early-life indoor environmental exposures increase the risk of childhood asthma
    Chen, Yang-Ching
    Tsai, Ching-Hui
    Lee, Yungling Leo
    [J]. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2011, 215 (01) : 19 - 25
  • [10] Early-life Household Environmental Exposures Increase the Risk of Childhood Asthma
    Chen, Yang-Ching
    Tsai, Ching-Hui
    Lee, Yungling
    [J]. EPIDEMIOLOGY, 2011, 22 (01) : S163 - S163