Formulation Development and Optimization of Flurbiprufen and Ranitidine Bilayer Tablet Designed by Central Composite Rotatable Design (CCRD) and Their In Vitro Kinetic Studies

Bilayer tablets of flurbiprofen SR and ranitidine IR was developed by using HPMC K4-M and colloidal silicon dioxide. Twenty formulations were planned by using design expert and micromeritic properties were analyzed for selection of six suitable formulations. Single punch machine was used for compression of bilayer tablets and physicochemical and quality control evaluation was performed successfully. Weight variation, hardness, friability and disintegration time were evaluated by pharmacopeial procedures. Release of ranitidine IR was studied for 60 min, while flurbiprofen SR was analysed for 24 h. In vitro kinetic studies like zero order, first order, Hixson-Crowell, and Weibull were applied to ranitidine IR formulation and flurbiprofen SR formulation was evaluated by zero order, first order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell and Weibull. Regression values of a first order in IR and zero order in SR were found to more than 0.97 and Weibull model was used to explain the shape factor formulation. S1 formulation was considered as the best one and was selected for further in vivo studies.