Two new steroidal saponins from Maianthemum henryi and their cytotoxic activity against human HepG2 tumor cells

被引：3

作者：

Lin, Jie ^{[1
]}

Wang, Guoquan ^{[1
]}

Bai, Lu ^{[2
]}

Yu, Linzhong ^{[3
]}

机构：

[1] Shaanxi Univ Chinese Med, Xianyang 712046, Peoples R China

[2] Xi An 1 Hosp, Xian, Shaanxi, Peoples R China

[3] Southern Med Univ, Guangzhou, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 24期

关键词：

Maianthemum henryi; steroidal saponins; structure evaluation; cytotoxicity; GLYCOSIDES; RHIZOMES; ROOTS; LEAVES;

D O I：

10.1080/14786419.2018.1514605

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new steroidal saponins (1 and 2), along with four known ones (3???6) were obtained from the roots and rhizomes of Maianthemum henryi, their structures were determined to be spirost-5, 25(27)-diene-l?, 3?-diol 1-O-?-L-rhamnopyranosyl-(1 ? 2)-4-O-acetyl-?-D-fucopyranoside (1), (23S, 24S)-spirost-5, 25(27)-diene-l?, 3?, 23, 24-tetrol 1-O-?-L-rhamnopyranosyl-(1 ? 2)-4-O-acetyl-?-D-fucopyranoside (2), spirost-5, 25(27)-diene-l?, 3?-diol 1-O-?-L-rhamnopyranosyl-(1 ? 2)-?-D-fucopyranoside (3), spirost-5, 25(27)-diene-l?, 3?-diol 1-O-?-L-rhamnopyranosyl-(1 ? 2)-?-D-xylopyranoside (4), Henryioside A (5)?Henryioside B (6), by physicochemical properties and spectroscopic methods. In addition, their cytotoxic activity against human HepG2 tumor cells was evaluated by MTT method and all of the compounds exhibited cytotoxicity with the cells.

引用

页码：3551 / 3558

页数：8

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