Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer

被引：9
|
作者：
Zhang, Yaping [1 ,2 ]
Qiu, Ling [3 ,4 ]
Wang, Yanmin [5 ]
He, Chengyan [6 ]
Qin, Xuzhen [3 ,4 ]
Liu, Yujie [1 ,2 ]
Li, Zhili [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biophys & Struct Biol, Beijing 100005, Peoples R China
[2] Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing 100005, Peoples R China
[4] Peking Union Med Coll, Beijing 100005, Peoples R China
[5] Heze Municipal Hosp, Dept Clin Lab, Heze, Peoples R China
[6] Jilin Univ, China Japan Union Hosp, Clin Lab Diag, Changchun 130023, Peoples R China
来源：
BIOMARKERS | 2014年 / 19卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Biomarker panel; early detection; gastric cancer; serum; unsaturated free fatty acids; CIRCULATING MICRORNAS; DIAGNOSTIC BIOMARKERS; METABOLIC-DISORDERS; ATROPHIC GASTRITIS; MASS-SPECTROMETRY; SERUM BIOMARKERS; RISK; IDENTIFICATION; PLASMA; CELLS;
D O I：
10.3109/1354750X.2014.977951
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C-16:1, C-18:3, C-18:2, C-18:1, C-20:4, and C-22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly decreased compared with 252 healthy controls. Receiver operating characteristic analysis showed that the biomarker panel including C-16:1, C-18:3, C-18:2, C-20:4, and C-22:6 presents a high diagnostic ability to differentiate early-stage GC patients from healthy controls plus BGD patients, with a sensitivity of 80.6% and a specificity of 72.7%.
引用
收藏
页码：667 / 673
页数：7
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