Metabolic Engineering and Regulation of Diol Biosynthesis from Renewable Biomass in Escherichia coli

被引:5
|
作者
Wu, Tong [1 ]
Liu, Yumei [1 ]
Liu, Jinsheng [1 ]
Chen, Zhenya [1 ]
Huo, Yi-Xin [1 ]
机构
[1] Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, 5 South Zhongguancun St, Beijing 100081, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
diols; metabolic engineering; carbon sources; regulation; Escherichia coli; HIGH-YIELD PRODUCTION; MICROBIAL-PRODUCTION; ETHYLENE-GLYCOL; E; COLI; 1,3-PROPANEDIOL PRODUCTION; EFFICIENT PRODUCTION; ENHANCED PRODUCTION; PATHWAY; ACID; GLYCEROL;
D O I
10.3390/biom12050715
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As bulk chemicals, diols have wide applications in many fields, such as clothing, biofuels, food, surfactant and cosmetics. The traditional chemical synthesis of diols consumes numerous non-renewable energy resources and leads to environmental pollution. Green biosynthesis has emerged as an alternative method to produce diols. Escherichia coli as an ideal microbial factory has been engineered to biosynthesize diols from carbon sources. Here, we comprehensively summarized the biosynthetic pathways of diols from renewable biomass in E. coli and discussed the metabolic-engineering strategies that could enhance the production of diols, including the optimization of biosynthetic pathways, improvement of cofactor supplementation, and reprogramming of the metabolic network. We then investigated the dynamic regulation by multiple control modules to balance the growth and production, so as to direct carbon sources for diol production. Finally, we proposed the challenges in the diol-biosynthesis process and suggested some potential methods to improve the diol-producing ability of the host.
引用
收藏
页数:19
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