Novel inhibitors of IMPDH: A highly potent and selective quinolone-based series

被引：26

作者：

Watterson, SH ^{[1
]}

Carlsen, M ^{[1
]}

Dhar, TGM ^{[1
]}

Shen, ZQ ^{[1
]}

Pitts, WJ ^{[1
]}

Guo, JQ ^{[1
]}

Gu, HH ^{[1
]}

Norris, D ^{[1
]}

Chorba, J ^{[1
]}

Chen, P ^{[1
]}

Cheney, D ^{[1
]}

Witmer, M ^{[1
]}

Fleener, CA ^{[1
]}

Rouleau, K ^{[1
]}

Townsend, R ^{[1
]}

Hollenbaugh, DL ^{[1
]}

Iwanowicz, EJ ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, PRI, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)00944-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：543 / 546

页数：4

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