Infections and Biological Therapy in Patients with Rheumatic Diseases

被引:0
|
作者
Atzeni, Fabiola [1 ]
Batticciotto, Alberto [2 ]
Masala, Ignazio F. [3 ]
Talotta, Rossella [2 ]
Benucci, Maurizio [4 ]
Sarzi-Puttini, Piercarlo [2 ]
机构
[1] IRCCS Galeazzi Orthoped Inst, Milan, Italy
[2] L Sacco Univ Hosp, Rheumatol Unit, GB Grassi 74, I-20127 Milan, Italy
[3] Santissima Trinita Hosp, Orthoped & Trauma Unit, Cagliari, Italy
[4] S Giovanni Dio Hosp, Rheumatol Unit, Florence, Italy
来源
ISRAEL MEDICAL ASSOCIATION JOURNAL | 2016年 / 18卷 / 3-4期
关键词
anti-tumor necrosis factor (TNF) drugs; newer biological drugs; fungal and viral infections; anti-CD20; anti-interleukin; 6; ANTI-TNF THERAPY; NECROSIS FACTOR THERAPY; HEPATITIS-B; SERIOUS INFECTIONS; BRITISH-SOCIETY; VIRUS-INFECTION; INCREASED RISK; ARTHRITIS; TUBERCULOSIS; REACTIVATION;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Long-term extension studies and observational drug registers have revealed an increased risk of serious infections in patients treated with anti-tumor necrosis factor agents, particularly infliximab, etanercept and adalimumab. The same may be true for the newer biological drugs rituximab, tocilizumab and abatacept, although this has yet to be confirmed by long-term observational studies. We review the risk of tuberculosis, herpes zoster and other opportunistic infections, and the recommendations for screening for tuberculosis and hepatitis B and C infections in patients with rheumatoid arthritis, with the aim of informing patients and encouraging greater awareness among physicians.
引用
收藏
页码:164 / 167
页数:4
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