Similar expression and regulation of Gli2 and Gli3 in the chick limb bud

被引：31
|
作者：
Schweitzer, R [1 ]
Vogan, KJ [1 ]
Tabin, CJ [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
来源：
MECHANISMS OF DEVELOPMENT | 2000年 / 98卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
Gli3; Sonic Hedgehog; chick; limb;
D O I：
10.1016/S0925-4773(00)00458-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Gli genes encode a family of zinc finger transcription factors that mediate signaling by Hedgehog proteins. We have cloned the chick Gli3 gene and studied its expression in developing chick limbs. Gli3 expression is highly similar to that of chick Gli2. Gli3 mRNA is evenly distributed in the early limb mesenchyme and subsequently downregulated in the posterior mesenchyme by the polarizing activity of Sonic hedgehog. At later stages, Gli3 is expressed in the distal limb mesenchyme. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：171 / 174
页数：4
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