Mapping the gene for sex-linked anemia: An inherited defect of intestinal iron absorption in the mouse

The sex-linked anemic (sla) mouse carries an anemia that results from an inherited defect of intestinal iron absorption and provides an ideal model with which to investigate this poorly understood yet clinically important process, We have precisely mapped the sin locus within the central region of the X chromosome in relation to a panel of microsatellite markers. Analysis of over 500 progeny from an intraspecific intercross and a smaller intraspecific backcross segregating sla established, the following locus order in the sin region: DXMit45-sla-(DXMit16, DXMit96)-DXMit41-DXMit169-DXMit170-DXMit148-(DXMit18, DXMit171)-DXMit84-DXMit64. The two microsatellites DXMit16 and DXMit96 are located 0.60 +/- 0.35cM from sla and form the telomeric limit of the sba region, The mapping of the sta locus is an important first seep to identifying the gene itself. (C) 1998 Academic Press.