Subclinical thyroid dysfunction and risk of carotid atherosclerosis

被引:14
|
作者
Kim, Hosu [1 ,2 ]
Kim, Tae Hyuk [1 ]
Kim, Hye In [1 ]
Park, So Young [1 ]
Kim, Young Nam [1 ]
Kim, Seonwoo [3 ]
Kim, Min-Ji [3 ]
Jin, Sang-Man [1 ]
Hur, Kyu Yeon [1 ]
Kim, Jae Hyeon [1 ]
Lee, Moon-Kyu [1 ]
Min, Yong-Ki [1 ]
Chung, Jae Hoon [1 ]
Kang, Mira [4 ]
Kim, Sun Wook [1 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med,Thyroid Ctr, Seoul, South Korea
[2] Gyeongsang Natl Univ, Changwon Hosp, Dept Med, Div Endocrinol, Chang Won, South Korea
[3] Samsung Biomed Res Inst, Stat & Data Ctr, Seoul, South Korea
[4] Samsung Med Ctr, Ctr Hlth Promot, Seoul, South Korea
来源
PLOS ONE | 2017年 / 12卷 / 07期
关键词
INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; SERUM-FREE THYROXINE; HEART-DISEASE; FOLLOW-UP; CARDIOVASCULAR HEALTH; EUTHYROID SUBJECTS; HYPOTHYROIDISM; ASSOCIATION; HYPERTHYROIDISM;
D O I
10.1371/journal.pone.0182090
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background The effect of subclinical thyroid dysfunction on vascular atherosclerosis remains uncertain. The objective of this study was to elucidate the association between sustained subclinical thyroid dysfunction and carotid plaques, which are an early surrogate marker of systemic atherosclerosis. Methods The study included 21,342 adults with consistent thyroid hormonal status on serial thyroid function tests (TFTs) and carotid artery duplex ultrasonography at a health screening center between 2007 and 2014. The effect of subclinical thyroid dysfunction on baseline carotid plaques and newly developed carotid plaques during 5-year follow-up was determined by logistic regression analyses and GEE (Generalized Estimating Equations), respectively. Results Carotid plaques were more common in the subclinical hypothyroidism (55.6%) than the euthyroidism (47.8%) at baseline. However, in multivariable analysis, thyroid status was not a significant risk for the carotid plaques at baseline. Instead, traditional cardiovascular risk factors, such as age (P < 0.001), systolic blood pressure (P = 0.023), fasting blood glucose (P = 0.030), and creatinine (P = 0.012) were associated with baseline carotid plaques in subclinical hypothyroidism. In longitudinal analyses of subjects who were followed up for more than 5 years, there was no significant difference in the cumulative incidence of new carotid plaques according to time between subjects with subclinical hypothyroidism and those with euthyroidism (P = 0.392). Conclusions Sustained subclinical thyroid dysfunction did not affect the baseline or development of carotid plaques in healthy individuals.
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页数:11
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