Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer

被引：10

作者：

Liu, Wen-Jing ^{[1
]}

Zhao, Gang ^{[2
]}

Zhang, Chen-Yan ^{[1
]}

Yang, Chang-Qing ^{[1
]}

Zeng, Xiang-Bin ^{[1
]}

Li, Jin ^{[1
]}

Zhu, Kun ^{[1
]}

Zhao, Shi-Qi ^{[1
]}

Lu, Hui-Meng ^{[1
]}

Yin, Da-Chuan ^{[1
]}

Lin, Sheng-Xiang ^{[3
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Inst Special Environm Biophys, Xian 710072, Shaanxi, Peoples R China

[2] First Hosp Jilin Univ, Breast Surg, Changchun, Jilin, Peoples R China

[3] Laval Univ, Lab Mol Endocrinol & Oncol, Dept Mol Med, CHUQ,CHUL,Res Ctr, Quebec City, PQ G1V 4G2, Canada

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2020年 / 121卷 / 04期

基金：

中国博士后科学基金; 加拿大健康研究院; 中国国家自然科学基金;

关键词：

estrogen; androgen; breast cancer; prostate cancer; RAT MAMMARY CARCINOGENESIS; INHIBITOR P21 GENE; RECEPTOR-BETA; AROMATASE INHIBITORS; TELOMERASE ACTIVITY; RESPONSE ELEMENT; ER-BETA; EXPRESSION; ACTIVATION; KINASE;

D O I：

10.1002/jcb.29515

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14% for BC and 9% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of androgen-induced PC. Androgen has dual effects on BC via different metabolic pathways, and the role of the androgen receptor (AR) in BC also depends on cell subtype and downstream target genes. Androgen and AR can stimulate both primary PC and castration-resistant PC. Understanding the mechanisms of the effects of estrogen and androgen on BC and PC may help us to improve curative BC and PC treatment strategies.

引用

页码：2756 / 2769

页数：14

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