Apoptosis induced by yessotoxins in Hela human cervical cancer cells in vitro

被引：10
|
作者：
Pang, Min [1 ]
Gao, Chun-Lei [2 ]
Wu, Zhen-Xing [3 ]
Lv, Ning [3 ]
Wang, Zong-Ling [2 ]
Tang, Xue-Xi [1 ]
Qu, Pei [2 ]
机构：
[1] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China
[2] State Ocean Adm, Inst Oceanog 1, Qingdao 266061, Peoples R China
[3] Shandong Entry Exit Inspect & Quarantine Bur, Ctr Tech, Qingdao 266002, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2010年 / 3卷 / 04期
关键词：
yessotoxins; apoptosis; Hela cells; PROTOCERATIUM-RETICULATUM; SHELLFISH; ACTIVATION; DEATH; NECROSIS; MUSSELS; PROFILE; TOXINS;
D O I：
10.3892/mmr_00000307
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the apoptotic effects of an extract of red-tide algae, Protoceratium reticulatum, on HeLa cells, we used liquid chromatography-tandem mass spectrometry, optical microscopy, Hoechst 33342/propidine iodide staining, and DNA gel electrophoresis to analyze its constituents and toxicity, as well as rhodamine 123 staining to investigate changes in mitochondrial membrane potential. Analysis showed that the P. reticulatum extract contained the yessotoxins (YTXs) homo-YTX, 45-OH-YTX and 45-OH-homo-YTX. The results indicated that P. reticulatum extract negatively influences HeLa cells and induces their apoptosis.
引用
收藏
页码：629 / 634
页数：6
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