Sirtuins and SIRT6 in Carcinogenesis and in Diet

被引：21

作者：

Teixeira, Maria de Ceu ^{[1
]}

Sanchez-Lopez, Elena ^{[2
,3
,4
]}

Espina, Marta ^{[2
,3
]}

Luisa Garcia, Maria ^{[2
,3
,4
]}

Durazzo, Alessandra ^{[5
]}

Lucarini, Massimo ^{[5
]}

Novellino, Ettore ^{[6
]}

Souto, Selma B. ^{[7
]}

Santini, Antonello ^{[6
]}

Souto, Eliana B. ^{[1
,8
]}

机构：

[1] Univ Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra, Portugal

[2] Univ Barcelona, Dept Pharm Pharmaceut Technol & Phys Chem, Fac Pharm & Food Sci, Av Joan XXIII 27-31, E-08028 Barcelona, Spain

[3] Univ Barcelona, Fac Pharm, Inst Nanosci & Nanotechnol IN2UB, E-08028 Barcelona, Spain

[4] Univ Barcelona, Fac Farm, CIBERNED Ctr Biomed Red Enfermedades Neurodegener, E-08028 Barcelona, Spain

[5] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy

[6] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[7] Hosp Sao Joao, Dept Endocrinol, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal

[8] Univ Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 19期

关键词：

sirtuins; SIRT6; cancer; modulator; chemotherapy; diet; HISTONE DEACETYLASE SIRT6; NF-KAPPA-B; DNA-REPAIR; GENOMIC INSTABILITY; CELL-PROLIFERATION; EMERGING ROLES; CANCER-CELLS; EXPRESSION; METABOLISM; PROTEIN;

D O I：

10.3390/ijms20194945

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine.

引用

页数：16

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