Modified bagging of maximal information coefficient for genome-wide identification

A new method, modified Bagging (mBagging) of Maximal Information Coefficient (mBoMIC), was developed for genome-wide identification. Traditional Bagging is inadequate to meet some requirements of genome-wide identification, in terms of statistical performance and time cost. To improve statistical performance and reduce time cost, an mBagging was developed to introduce Maximal Information Coefficient (MIC) into genome-wide identification. The mBoMIC overcame the weakness of original MIC, i.e., the statistical power is inadequate and MIC values are volatile. The three incompatible measures of Bagging, i.e. time cost, statistical power and false positive rate, were significantly improved simultaneously. Compared with traditional Bagging, mBagging reduced time cost by 80%, improved statistical power by 15%, and decreased false positive rate by 31%. The mBoMIC has sensitivity and university in genome-wide identification. The SNPs identified only by mBoMIC have been reported as SNPs associated with cardiac disease.