Cyclin-dependent kinases in DNA damage response

被引：46

作者：

Kciuk, Mateusz ^{[1
,2
]}

Gieleci, Adrianna ^{[1
]}

Mujwar, Somdutt ^{[3
]}

Mojzych, Mariusz ^{[4
]}

Kontek, Renata ^{[1
]}

机构：

[1] Univ Lodz, Dept Mol Biotechnol & Genet, Lab Cytogenet, Banacha 12-16, PL-90237 Lodz, Poland

[2] Univ Lodz, Doctoral Sch Exact & Nat Sci, Banacha St 12-16, PL-90237 Lodz, Poland

[3] Maharishi Markandeshwar Deemed Univ Mullana, MM Coll Pharm, Ambala 133207, Haryana, India

[4] Siedlce Univ Nat Sci & Humanities, Dept Chem, 3 Maja 54, PL-08110 Siedlce, Poland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2022年 / 1877卷 / 03期

关键词：

Cyclin-dependent kinase (CDK); Cell-cycle checkpoint; DNA damage response (DDR); DNA repair;

D O I：

10.1016/j.bbcan.2022.188716

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs in DNA damage response (DDR) has emerged. CDKs affect both damage signaling and DNA repair, contributing to the fidelity of the cell division process as well as the maintenance of genomic integrity following DNA damage. This is due to the modulatory role of CDKs on double-strand break repair (DSBR) components, including their influence on enzymes involved in homologous recombination (HR) and non-homologous end-joining (NHEJ). In this review, the impact of CDKs on DDR and DNA repair is discussed.

引用

页数：7

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