Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line

被引：11
|
作者：
Tabassum, Fatema [1 ,2 ]
Hasan, Choudhury Mahmood [1 ]
Masud, Mohammad Mehedi [1 ]
Jamshidi, Shirin [3 ]
Rahman, Khondaker Miraz [3 ]
Ahsan, Monira [1 ]
机构：
[1] Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh
[2] Northern Univ Bangladesh, Dept Pharm, Dhaka 1205, Bangladesh
[3] Kings Coll London, Inst Pharmaceut Sci, 150 Stamford St, London SE1 9NH, England
来源：
PHYTOCHEMISTRY | 2021年 / 186卷
关键词：
Ravenia spectabilis Engl; Rutaceae; Indole alkaloid; Pancreatic cancer; Molecular modelling; DNA interactive agents; ANTIBACTERIAL ACTIVITY; RUTACEAE; CYTOTOXICITY; EXTRACTIVES; MEDICINE;
D O I：
10.1016/j.phytochem.2021.112744
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two previously undescribed indole alkaloids, 3-prenyl-5(3-keto-but-1-enyl) indole and 3-prenyl-indole-5-carbaldehyde, the structurally-related 3,5-diprenyl indole and four known alkaloids were isolated from the leaves of Ravenia spectabilis Engl. Structures were elucidated based on nuclear magnetic resonance (1D and 2D NMR) spectroscopic and mass spectrometric analysis. The previously undescribed compounds isolated were subsequently screened against the HeLa (human cervical cancer), MIA PaCa-2 (human pancreatic adenocarcinoma) and A549 (lung cancer) cell lines. Among the isolated compounds, 3,5-diprenyl indole was the most cytotoxic across all three cell lines (MIA PaCa-2 IC50 = 9.5 +/- 2.2 mu M). Molecular modelling studies suggested DNA intercalation as the mode of action of these compounds.
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页数：5
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