Bacteria of the genus Deinococcus exhibit an extraordinary ability to withstand the lethal and mutagenic effects of DNA damaging agents-particularly the effects of ionizing radiation. These bacteria are the most DNA damage-tolerant organisms ever identified. Relatively little is known about the biochemical basis for this phenomenon; however, available evidence indicates that efficient repair of DNA damage is, in large part, responsible for the deinococci's radioresistance. Obviously, an explanation of the deinococci's DNA damage tolerance cannot be developed solely on the basis of the DNA repair strategies of more radiosensitive organisms. The deinococci's capacity to survive DNA damage suggests that (a) they employ repair mechanisms that are fundamentally different from other prokaryotes, or that (b) they have the ability to potentiate the effectiveness of the conventional complement of DNA repair proteins. An argument is made for the latter alternative.
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Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Open Univ, Dept Phys & Astron, Milton Keynes MK7 6AA, Bucks, EnglandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Paulino-Lima, Ivan Glaucio
Janot-Pacheco, Eduardo
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Univ Sao Paulo, Inst Astron Geofis & Ciencias Atmosfer, Sao Paulo, Brazil
Open Univ, Dept Phys & Astron, Milton Keynes MK7 6AA, Bucks, EnglandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Janot-Pacheco, Eduardo
Galante, Douglas
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Univ Sao Paulo, Inst Astron Geofis & Ciencias Atmosfer, Sao Paulo, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Galante, Douglas
Cockell, Charles
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Open Univ, Planetary & Space Sci Res Inst, Milton Keynes MK7 6AA, Bucks, EnglandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Cockell, Charles
Olsson-Francis, Karen
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Open Univ, Planetary & Space Sci Res Inst, Milton Keynes MK7 6AA, Bucks, EnglandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Olsson-Francis, Karen
Brucato, John Robert
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Osserv Astrofis Arcetri, INAF, I-50125 Florence, ItalyUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Brucato, John Robert
Baratta, Giuseppe Antonio
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Osserv Astrofis Catania, INAF, I-95125 Catania, ItalyUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Baratta, Giuseppe Antonio
Strazzulla, Giovanni
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Osserv Astrofis Catania, INAF, I-95125 Catania, ItalyUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Strazzulla, Giovanni
Merrigan, Tony
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Queens Univ Belfast, Sch Math & Phys, Ctr Plasma Phys, Belfast BT7 1NN, Antrim, North IrelandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Merrigan, Tony
McCullough, Robert
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Queens Univ Belfast, Sch Math & Phys, Ctr Plasma Phys, Belfast BT7 1NN, Antrim, North IrelandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
McCullough, Robert
Mason, Nigel
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Open Univ, Dept Phys & Astron, Milton Keynes MK7 6AA, Bucks, EnglandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Mason, Nigel
Lage, Claudia
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Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
Open Univ, Dept Phys & Astron, Milton Keynes MK7 6AA, Bucks, EnglandUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil
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Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil NaduDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu
Maqbool I.
Ponniresan V.
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Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil NaduDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu
Ponniresan V.
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Govindasamy K.
Prasad N.R.
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Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil NaduDepartment of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu