Flavylium Polymethine Fluorophores for Near- and Shortwave Infrared Imaging

被引：324

作者：

Cosco, Emily D. ^{[1
]}

Caram, Justin R. ^{[2
]}

Bruns, Oliver T. ^{[2
]}

Franke, Daniel ^{[2
]}

Day, Rachael A. ^{[1
]}

Farr, Erik P. ^{[1
]}

Bawendi, Moungi G. ^{[2
]}

Sletten, Ellen M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 42期

关键词：

fluorescent dyes; imaging agents; near-infrared; polymethines; shortwave infrared; HEPTAMETHINE CYANINE DYES; FLUORESCENT LABELS; QUANTUM DOTS; PHOTOLUMINESCENCE; PHOTOSTABILITY;

D O I：

10.1002/anie.201706974

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bright fluorophores in the near-infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging invivo. In this work, we utilized a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted polymethine dyes, with emission wavelengths from 680 to 1045nm. Photophysical characterization revealed that the 1- and 3-methine dyes display enhanced photostability and the 5- and 7-methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7-methine facilitated SWIR imaging in mice. This report presents the first polymethine dye designed and synthesized for SWIR invivo imaging.

引用

页码：13126 / 13129

页数：4

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