Discrimination of Thermophilic and Mesophilic Proteins

There has been considerable interest in the physical basis for the increased thermostability of thermophilic proteins with respect to their mesophilic counterparts since the discovery of highly thermo-tolerant organisms. We have systematically studied a large set of protein structures in order to find those properties with the most power to discriminate mesophilic proteins from their thermophilic orthologs. Most of the structure-based descriptors used in our discrimination and classification experiments were derived from the Delaunay tessellations of the protein structures.