Time- and sex-dependent associations between prenatal alcohol exposure

被引：28

作者：

Loke, Yuk Jing ^{[1
]}

Muggli, Evelyne ^{[2
,3
]}

Nguyen, Linh ^{[1
]}

Ryan, Joanne ^{[3
,4
,5
]}

Saffery, Richard ^{[3
,5
]}

Elliott, Elizabeth J. ^{[6
,7
]}

Halliday, Jane ^{[2
,3
]}

Craig, Jeffrey M. ^{[1
,3
,8
]}

机构：

[1] Royal Childrens Hosp, Environm & Genet Epidemiol Res, Murdoch Childrens Res Inst, Flemington Rd, Parkville, Vic 3052, Australia

[2] Royal Childrens Hosp, Publ Hlth Genet, Murdoch Childrens Res Inst, Flemington Rd, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[4] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia

[5] Royal Childrens Hosp, Canc & Dis Epigenet, Murdoch Childrens Res Inst, Flemington Rd, Parkville, Vic 3052, Australia

[6] Univ Sydney, Discipline Child & Adolescent Hlth, Sch Med & Hlth, Sydney, NSW 2006, Australia

[7] Sydney Childrens Hosp Network, Australian Paediat Surveillance Unit, Sydney, NSW, Australia

[8] Deakin Univ, Ctr Mol & Med Res, Geelong Waurn Ponds Campus,Locked Bag 20000, Geelong, Vic 3220, Australia

来源：

EPIGENOMICS | 2018年 / 10卷 / 07期

基金：

英国医学研究理事会;

关键词：

global DNA methylation; placenta; prenatal alcohol exposure; DNA METHYLATION ANALYSIS; HUMAN PLACENTA; IN-UTERO; EXECUTIVE FUNCTION; PROSPECTIVE COHORT; MULTIPLE TISSUES; INCREASED RISK; NEWBORN TWINS; PREGNANCY; CONSUMPTION;

D O I：

10.2217/epi-2017-0147

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: Epigenetic changes, in particular in the placenta, may mediate the effects of prenatal alcohol exposure (PAE) on children's health. We examined the relationship between PAE patterns, based on dose and timing, and placental global DNA methylation. Methods: Using linear regression analysis, we examined the association between different PAE categories and placental global DNA methylation (n = 187), using the proxy measure of Alu-interspersed repeats. Results: Following adjustment for important covariates, we found no evidence of an association between PAE and placental global DNA methylation overall. However, when stratifying by newborn sex, PAE throughout pregnancy was associated with higher placental global DNA methylation (1.5%; p = 0.01) of male newborns. Conclusion: PAE may have sex-specific effects on placental global DNA methylation if alcohol is consumed throughout pregnancy.

引用

页码：981 / 991

页数：11

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