Microenvironment of Tumor-Draining Lymph Nodes: Opportunities for Liposome-Based Targeted Therapy

被引:59
|
作者
Chandrasekaran, Siddarth [1 ]
King, Michael R. [1 ]
机构
[1] Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA
来源
关键词
tumor microenvironment; liposomes; nanomedicine; metastasis; tumor-draining lymph nodes; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; PLASMACYTOID DENDRITIC CELLS; ANTIGEN-CONTAINING LIPOSOMES; INTERSTITIAL FLUID PRESSURE; APOPTOSIS-INDUCING LIGAND; HIGH-DOSE INTERLEUKIN-2; PH-SENSITIVE LIPOSOMES; BREAST-CANCER; METASTATIC MELANOMA;
D O I
10.3390/ijms151120209
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The World Health Organization (WHO) recently reported that the total number of global cancer cases in 2013 reached 14 million, a 10% rise since 2008, while the total number of cancer deaths reached 8.2 million, a 5.2% increase since 2008. Metastasis is the major cause of death from cancer, accounting for 90% of all cancer related deaths. Tumor-draining lymph nodes (TDLN), the sentinel nodes, are the first organs of metastasis in several types of cancers. The extent of metastasis in the TDLN is often used in disease staging and prognosis evaluation in cancer patients. Here, we describe the microenvironment of the TDLN and review the recent literature on liposome-based therapies directed to immune cells within the TDLN with the intent to target cancer cells.
引用
收藏
页码:20209 / 20239
页数:31
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