A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth

被引：18
|
作者：
Zhang, L. [1 ]
Gao, L. [2 ]
Shao, M. [1 ]
Sun, G. Y. [3 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Dept Crit Care Med, Hefei, Anhui, Peoples R China
[2] Anhui Med Univ, Hosp 2, Dept Resp & Crit Care Med, Hefei, Anhui, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Hefei, Anhui, Peoples R China
来源：
NEOPLASMA | 2019年 / 66卷 / 06期
基金：
中国国家自然科学基金;
关键词：
NSCLC; lncRNA; MYC; GATA2; C-MYC; EXPRESSION; REPRESSION; ONCOGENE; PROTEIN; GATA-2; REGION; GENE;
D O I：
10.4149/neo_2019_190210N112
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-small cell lung cancer (NSCLC) is the most prevalent subtype of lung cancer histologically, and an increasing number of evidences have shown during the past years that long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Here we found a long non-coding RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. To conclude, our study discovered the role of lncRNA GATA2-AS1 in human non-small cell lung cancer growth thus providing a potential target for lung cancer drugs.
引用
收藏
页码：954 / 962
页数：9
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