High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography

被引:11
|
作者
Kim, Sangmin [1 ]
Raphael, Patrick D. [2 ]
Oghalai, John S. [2 ]
Applegate, Brian E. [1 ]
机构
[1] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA
[2] Stanford Univ, Dept Otolaryngol Head & Neck Surg, Stanford, CA 94305 USA
来源
BIOMEDICAL OPTICS EXPRESS | 2016年 / 7卷 / 04期
基金
美国国家卫生研究院;
关键词
RETINAL BLOOD-FLOW; SWEPT-SOURCE; DOPPLER TOMOGRAPHY; ANTERIOR SEGMENT; MOUSE COCHLEA; MIDDLE-EAR; DOMAIN OCT; ELASTOGRAPHY; DEFORMATION; STRAIN;
D O I
10.1364/BOE.7.001430
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Swept-laser sources offer a number of advantages for Phase-sensitive Optical Coherence Tomography (PhOCT). However, inter-and intra-sweep variability leads to calibration errors that adversely affect phase sensitivity. While there are several approaches to overcoming this problem, our preferred method is to simply calibrate every sweep of the laser. This approach offers high accuracy and phase stability at the expense of a substantial processing burden. In this approach, the Hilbert phase of the interferogram from a reference interferometer provides the instantaneous wavenumber of the laser, but is computationally expensive. Fortunately, the Hilbert transform may be approximated by a Finite Impulse-Response (FIR) filter. Here we explore the use of several FIR filter based Hilbert transforms for calibration, explicitly considering the impact of filter choice on phase sensitivity and OCT image quality. Our results indicate that the complex FIR filter approach is the most robust and accurate among those considered. It provides similar image quality and slightly better phase sensitivity than the traditional FFT-IFFT based Hilbert transform while consuming fewer resources in an FPGA implementation. We also explored utilizing the Hilbert magnitude of the reference interferogram to calculate an ideal window function for spectral amplitude calibration. The ideal window function is designed to carefully control sidelobes on the axial point spread function. We found that after a simple chromatic correction, calculating the window function using the complex FIR filter and the reference interferometer gave similar results to window functions calculated using a mirror sample and the FFT-IFFT Hilbert transform. Hence, the complex FIR filter can enable accurate and high-speed calibration of the magnitude and phase of spectral interferograms. (C) 2016 Optical Society of America
引用
收藏
页码:1430 / 1444
页数:15
相关论文
共 50 条
  • [1] Optical coherence tomography with phase-sensitive light
    Erkmen, Baris I.
    Shapiro, Jeffrey H.
    [J]. QUANTUM COMMUNICATIONS AND QUANTUM IMAGING IV, 2006, 6305
  • [2] High speed imaging of remotely induced shear waves using phase-sensitive optical coherence tomography
    Song, Shaozhen
    Le, Nhan Minh
    Huang, Zhihong
    Wang, Ruikang K.
    [J]. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XIX, 2015, 9312
  • [3] In vivo imaging with high-speed full range complex spectral domain optical coherence tomography
    Goetzinger, E
    Pircher, M
    Leitgeb, R
    Fercher, AF
    Hitzenberger, CK
    [J]. Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 2005, 5690 : 121 - 126
  • [4] High-speed complex conjugate resolved retinal spectral domain optical coherence tomography using sinusoidal phase modulation
    Tao, Yuankai K.
    Zhao, Mingtao
    Izatt, Joseph A.
    [J]. OPTICS LETTERS, 2007, 32 (20) : 2918 - 2920
  • [5] High-Speed Polarization Sensitive Optical Coherence Tomography for Retinal Diagnostics
    Yin, Biwei
    Wang, Bingqing
    Vemishetty, Kalyanramu
    Nagle, Jim
    Liu, Shuang
    Wang, Tianyi
    Rylander, Henry G., III
    Milner, Thomas E.
    [J]. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVI, 2012, 8213
  • [6] High-resolution High-speed Spectral Domain Optical Coherence Tomography
    Song, Cheol
    Ahn, MyoungKi
    Gweon, DaeGab
    Cho, HyungSuck
    [J]. ISOT: 2009 INTERNATIONAL SYMPOSIUM ON OPTOMECHATRONIC TECHNOLOGIES, 2009, : 11 - +
  • [7] Phase-sensitive high-speed THz imaging
    Hattori, T
    Ohta, K
    Rungsawang, R
    Tukamoto, K
    [J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2004, 37 (05) : 770 - 773
  • [8] Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry
    Subhash, Hrebesh M.
    Anh Nguyen-Huynh
    Wang, Ruikang K.
    Jacques, Steven L.
    Choudhury, Niloy
    Nuttall, Alfred L.
    [J]. JOURNAL OF BIOMEDICAL OPTICS, 2012, 17 (06)
  • [9] Ultra high-speed spectral domain optical coherence tomography of the human retina
    Nassif, NA
    Cense, B
    Park, BH
    Pierce, MC
    Bouma, B
    Tearney, GJ
    de Boer, JF
    [J]. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VIII, 2004, 5316 : 233 - 235
  • [10] High-speed spectral domain optical coherence tomography for imaging of biological tissues
    Ma, ZH
    Wang, RK
    Zhang, F
    Yao, JQ
    [J]. OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS: DIAGNOSTICS AND TREATMENT II , PTS 1 AND 2, 2005, 5630 : 286 - 294