Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia

被引：31
|
作者：
Stepan, Holger [2 ]
Kralisch, Susan [1 ]
Klostermann, Katrin [2 ]
Schrey, Susanne [2 ]
Reisenbuechler, Constanze [2 ]
Verlohren, Michael [3 ]
Verlohren, Hans-Joachim [3 ]
Drynda, Kathrin [4 ]
Blueher, Matthias [1 ]
Stumvoll, Michael [1 ]
Kratzsch, Juergen [5 ]
Kovacs, Peter [1 ,6 ]
Fasshauer, Mathias [1 ]
机构：
[1] Univ Leipzig, Dept Internal Med 3, D-04103 Leipzig, Germany
[2] Univ Leipzig, Dept Obstet, D-04103 Leipzig, Germany
[3] Outpatient Care Unit, D-04177 Leipzig, Germany
[4] Outpatient Care Unit, D-04103 Leipzig, Germany
[5] Univ Leipzig, Inst Lab Med, D-04103 Leipzig, Germany
[6] IZKF Leipzig, D-04103 Leipzig, Germany
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2010年 / 59卷 / 07期
关键词：
ACID-BINDING PROTEIN; SERUM-LEVELS; ADIPONECTIN; LEPTIN; RISK; ADIPOCYTOKINE;
D O I：
10.1016/j.metabol.2009.11.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The objective of the study was to investigate serum levels of the insulin-sensitizing adipokine vaspin in patients with gestational diabetes mellitus (GDM) and preeclampsia (PE) as compared with healthy controls of similar gestational age. Vaspin serum levels were quantified by enzyme-linked immunosorbent assay in control (n = 102), GDM (n = 40), and PE (n = 22) subjects. Median maternal vaspin concentrations were not significantly different in GDM, PE, and control subjects. Furthermore, vaspin did not significantly correlate to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation. Circulating vaspin levels are not significantly different between GDM, PE, and control subjects and do not correlate with insulin sensitivity in pregnant subjects. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：1054 / 1056
页数：3
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