Pharmacotherapies for Posttraumatic Stress Disorder A Meta-Analysis

被引：13

作者：

Gu, Wenjie ^{[1
]}

Wang, Chao ^{[1
]}

Li, Zuofeng ^{[1
]}

Wang, Zhen ^{[2
]}

Zhang, Xiaoyan ^{[1
]}

机构：

[1] Tongji Univ, Sch Life Sci & Technol, 1239 Siping Rd, Shanghai 200092, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China

来源：

JOURNAL OF NERVOUS AND MENTAL DISEASE | 2016年 / 204卷 / 05期

关键词：

PTSD; randomized clinical trial; pharmacotherapy; F1; score; DOUBLE-BLIND; SERTRALINE TREATMENT; CONTROLLED-TRIAL; CHRONIC PTSD; ODDS RATIO; PLACEBO; FLUOXETINE; EFFICACY; METAANALYSIS; VETERANS;

D O I：

10.1097/NMD.0000000000000478

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of this study was to assess the acceptability and efficacy of all types of pharmacotherapeutic agents in reducing the symptoms of post-traumatic stress disorder (PTSD). In this systematic meta-analysis, the dropout and response rates of various pharmacotherapy and placebo treatments reported by randomized clinical trials were compared. A total of 34 reports that described the acceptability and efficacy of PTSD pharmacotherapies were retrieved and analyzed. Of them, 30 trials examined the dropout rate as an index of acceptability and revealed the superiority of the PTSD pharmacotherapy to placebos (odds ratio, 0.75; 95% confidence interval, 0.66-0.86; n = 4313). The response rate was determined in 20 trials as an index of efficacy, showing that the PTSD pharmacotherapies were superior to the placebos (odds ratio, 1.47; 95% confidence interval, 1.34-1.62; n = 2166). Pharmacotherapy is an important component of the care of patients with PTSD.

引用

页码：331 / 338

页数：8

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