mGluR-mediated calcium signalling in the thalamic reticular nucleus

被引：10

作者：

Neyer, Christina ^{[1
,3
]}

Herr, David ^{[1
]}

Kohmann, Denise ^{[1
]}

Budde, Thomas ^{[1
]}

Pape, Hans-Christian ^{[1
]}

Coulon, Philippe ^{[1
,2
]}

机构：

[1] Univ Munster, Inst Physiol 1, D-48149 Munster, Germany

[2] Seattle Childrens Res Inst, Ctr Integrat Brain Res, Seattle, WA USA

[3] Univ Klinikum Munster, Klin Allgemeine Neurol, Munster, Germany

来源：

CELL CALCIUM | 2016年 / 59卷 / 06期

关键词：

Thalamic reticular nucleus; Metabotropic glutamate receptors; Thalamus; Calcium; IP3; receptors; Calcium activated nonselective cation conductance; Genetic absence epilepsy rats from strasbourg; METABOTROPIC GLUTAMATE RECEPTORS; LATERAL GENICULATE-NUCLEUS; FUNCTIONAL-PROPERTIES; ELECTRICAL SYNAPSES; CA2+ CHANNELS; GROUP-II; NEUROTRANSMITTER ACTIONS; GABAERGIC NEURONS; CATION CHANNELS; CELL-TYPE;

D O I：

10.1016/j.ceca.2016.03.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The thalamic reticular nucleus (TRN) plays a major foie in modulating the transfer of information from the thalamus to the cortex. GABAergic inhibition via the TRN is differentially regulated by metabotropic glutamate receptors (mGluRs) and the effect of mGluRs on the membrane potential, on ion channels, and on the plasticity of electrical coupling of TRN neurons has been studied previously. Although mGluRs are generally known to trigger Ca2+ transients, mGluR-mediated Ca2+-transients in TRN neurons have not yet been investigated. In this study, we show that mGluRs can trigger Ca2+-transients in TRN neurons, that these transients depend on intracellular Ca2+-stores, and are mediated by IP3 receptors. Ca2+ transients caused by the group I mGluR agonist DHPG elicit a current that is sensitive to flufenamic acid and has a reversal potential around-40 mV. Our results add mGluR-mediated Ca2+-signalling in the TRN to the state-dependent modulators of the thalamocortical system. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：312 / 323

页数：12

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