Assessment of 17α-ethinylestradiol effects in Daphnia magna: life-history traits, biochemical and genotoxic parameters

被引:14
|
作者
Rodrigues, Sara [1 ,2 ]
Silva, Ana Marta [1 ]
Antunes, Sara Cristina [1 ,2 ]
机构
[1] Univ Porto, Fac Ciencias, Dept Biol, Rua Campo Alegre S-N, P-4169007 Porto, Portugal
[2] Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental, CIMAR CIIMAR, Matosinhos, Portugal
关键词
Biomarkers; Chronic exposure; Life-history parameters; Non-target organisms; Oral contraceptive; Water contamination; SEWAGE-TREATMENT PLANTS; ENDOCRINE-DISRUPTING CHEMICALS; SOLID-PHASE EXTRACTION; SURFACE-WATER; AQUATIC ENVIRONMENT; SYNTHETIC ESTROGEN; GENE-EXPRESSION; DRINKING-WATER; WASTE-WATER; END-POINTS;
D O I
10.1007/s11356-020-12323-5
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The occurrence of pharmaceuticals in aquatic ecosystems and the need to study them have increased over the years since they enter continuously the environment. Besides, these compounds are not intended for applications with environmental purposes, and therefore, little is known about their ecological effects, particularly in non-target organisms, as invertebrate species. Inside these substances, endocrine disrupting compounds (EDCs) have recently come into the limelight, due to environmental concentrations and consequently their detrimental effects on different organisms. 17 alpha-ethinylestradiol (EE2) has been detected in the aquatic environment in various locations around the globe since it is the main synthetic hormone used as a female oral contraceptive and is also applied in veterinary medicine and animal production. The present study was intended to assess the chronic effects of EE2, in the non-target organism as Daphnia magna. Thus, to analyze the individual and subindividual impact, this aquatic organism was chronically exposed (21 days) to 0.00 (control group), 0.10, 1.00, 10.0, and 100 mu g/L of EE2. Results here obtained demonstrated that D. magna exposed to the EE2 concentrations had significant effects in individual (life-history) and sub-individual (biochemical levels) parameters. Alterations as anticipation in the age at first reproduction, a decrease of the growth rate, oxidative stress, and lipid peroxidation were detected, as well as genotoxic damage. Therefore, it was possible to infer that EE2 can disrupt several metabolic pathways and physiological functions of D. magna, since EE2 demonstrated ecotoxicity, at environmentally relevant concentrations. This work reinforces the importance of examining the effects of more relevant exposures (more prolonged and with ecologically pertinent concentrations) of potential endocrine disruptors like EE2, to the freshwater organisms and ecosystem.
引用
收藏
页码:23160 / 23173
页数:14
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