Some opinions are put forward about the balance and compatibility of design perspective and usability in the human-machine interface design. By introducing the human attributes, realistic rationality of human, inductive rationality of thought and other potential influence power in the human-machine interface design, the appropriate insertion point should be chosen and balanced in design to satisfy people's needs. The universal design is introduced because of its advantages of inclusivity. The product interface can be designed by way of universal design principle in the small scope. By analyzing the principles of design usability, human-machine interface should be designed in a target-oriented way according to different consumer groups in order to make more humanized. The human-machine interface design should be paid more attention to both the appearance and usable function of interface.