On the anti-inflammatory and anti-phospholipase A2 activity of extracts from lanostane-rich species

被引：75

作者：

Giner-Larza, EM ^{[1
]}

Máñez, S ^{[1
]}

Giner-Pons, RM ^{[1
]}

Recio, MC ^{[1
]}

Ríos, JL ^{[1
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Farmacol, E-46100 Burjassot, Valencia, Spain

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 73卷 / 1-2期

关键词：

anti-inflammatory activity; Poria cocos; Pistacia terebinthus; Ganoderma lucidum; phospholipase A(2) inhibition;

D O I：

10.1016/S0378-8741(00)00276-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA(2). The inhibitory effect against PLA(2) in vitro was also studied. When the Poria cocos extract was tested against PLA(2)-induced mouse paw edema, it was active by the oral and parenteral routes. Its effect was greater in both magnitude and duration than that of Pistacia terebinthus and Ganoderma lucidum extracts. P. terebinthus was effective against chronic and acute inflammation, and according to a preliminary chromatographic analysis, its seems to be a good source of lanostane anti-inflammatory agents. G. lucidum? was the least effective of the three species studied and, unlike the other two, failed to inhibit the, activity of PLA(2) in vitro. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：61 / 69

页数：9

共 50 条

[1] Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus
Sala, A
Recio, MC
Giner, RM
Máñez, S
Ríos, JL
LIFE SCIENCES, 1999, 66 (02) : PL35 - PL40
[2] Modulation of Phospholipase A2 Membrane Activity by Anti-inflammatory Drugs
Jaramillo-Granada, Angela M.
Li, Jinhui
Flores Villarreal, Aneliza
Lozano, Omar
Ruiz-Suarez, J. C.
Monje-Galvan, Viviana
Sierra-Valdez, Francisco J.
LANGMUIR, 2024, 40 (13) : 7038 - 7048
[3] Anti-inflammatory Activity of Oleanolic Acid by Inhibition of Secretory Phospholipase A2
Dharmappa, Kattepura K.
Kumar, Raju Venkatesh
Nataraju, Angaswamy
Mohamed, Riyaz
Shivaprasad, Holenarasipura V.
Vishwanath, Bannikuppe S.
PLANTA MEDICA, 2009, 75 (03) : 211 - 215
[4] A biophysical approach to phospholipase A2 activity and inhibition by anti-inflammatory drugs
Gaspar, Diana
Lucio, Marlene
Wagner, Kerstin
Brezesinski, Gerald
Rocha, Sandra
Costa Lima, J. L. F.
Reis, Salette
BIOPHYSICAL CHEMISTRY, 2010, 152 (1-3) : 109 - 117
[5] α-lipoic acid:: An inhibitor of secretory phospholipase A2 with anti-inflammatory activity
Jameel, Noor Mohamed
Shekhar, Mysore A.
Vishwanath, Bannikuppe S.
LIFE SCIENCES, 2006, 80 (02) : 146 - 153
[6] Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy: More Evidence for Pathogenicity of Anti-phospholipase A2 Receptor Autoantibodies
Brenchley, Paul E. C.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (10): : 2308 - 2311
[7] Phospholipase A2 inhibitors as potential anti-inflammatory agents
Meyer, MC
Rastogi, P
Beckett, CS
McHowat, J
CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (10) : 1301 - 1312
[8] Anti-Phospholipase A2 Receptor Antibody in Membranous Nephropathy
Qin, Weisong
Beck, Laurence H., Jr.
Zeng, Caihong
Chen, Zhaohong
Li, Shijun
Zuo, Ke
Salant, David J.
Liu, Zhihong
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (06): : 1137 - 1143
[9] Functional site of endogenous phospholipase A2 inhibitor from python']python serum -: Phospholipase A2 binding and anti-inflammatory activity
Thwin, MM
Satish, RL
Chan, STF
Gopalakrishnakone, P
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (02): : 719 - 727
[10] Effects of anti-phospholipase A2 on the growth of rainbow trout
Barry, Terence P.
Yang, Mingder
NORTH AMERICAN JOURNAL OF AQUACULTURE, 2008, 70 (02) : 236 - 239

← 1 2 3 4 5 →