Intrathecal Methotrexate Toxicity Resulting in Brain Death due to Generalized Cerebral Edema Case Report

被引：1

作者：

Pang, Haoming ^{[1
]}

Chan, Julie L. ^{[1
]}

Bannykh, Serguei, I ^{[2
]}

Gezalian, Michael ^{[1
]}

Lahiri, Shouri ^{[1
]}

Toossi, Shahed ^{[1
]}

Ayodele, Maranatha ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Neurol, 127 S San Vicente Blvd,Suite A6600, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

来源：

NEUROHOSPITALIST | 2022年 / 12卷 / 04期

关键词：

case report; intrathecal methotrexate; breast cancer; cerebral edema; carcinomatosis; CEREBROSPINAL-FLUID-FLOW; TUMOR LYSIS; CHEMOTHERAPY; CANCER;

D O I：

10.1177/19418744221106313

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intrathecal methotrexate (IT MTX) resulting in severe adverse events including life-threatening cerebral edema is not well described. We report a rare case of death in a 37-year-old BRCAI + woman with metastatic triple-negative breast cancer status post mastectomy following administration of IT MTX for leptomeningeal carcinomatosis. Within the 24 hours after intraoperative IT MTX delivery, she developed neurologically devastating diffuse cerebral edema leading to uncal and cerebellar tonsillar herniation. This case report highlights a rare but devastating side effect of IT MTX.

引用

页码：697 / 701

页数：5

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