Blood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of death

被引:5
|
作者
Hestad, Knut Asbjorn [1 ,2 ]
Engedal, Knut [3 ,4 ]
Selbaek, Geir [3 ,4 ,6 ]
Strand, Bjorn Heine [3 ,4 ,5 ]
机构
[1] Inland Norway Univ Appl Sci, Fac Hlth & Social Sci, Dept Hlth & Nursing Sci, Postboks 400, N-2418 Elverum, Norway
[2] Innlandet Hosp Trust, Dept Res, Ottestad, Norway
[3] Vestfold Cty Hosp Trust, Norwegian Natl Advisory Unit Ageing & Hlth, Tonsberg, Norway
[4] Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway
[5] Norwegian Inst Publ Hlth, Oslo, Norway
[6] Univ Oslo, Fac Med, Oslo, Norway
来源
BRAIN AND BEHAVIOR | 2021年 / 11卷 / 07期
关键词
aging; blood pressure; death; dementia; mild cognitive impairment; sex; sex differences; systolic; CORONARY-HEART-DISEASE; RISK-FACTORS; LATE-LIFE; ALZHEIMERS-DISEASE; ALL-CAUSE; ASSOCIATION; MIDLIFE; AGE; MORTALITY; OLD;
D O I
10.1002/brb3.2166
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective It is unknown whether systolic blood pressure (SBP) drop is part of the normal aging process or due to the onset of dementia for some people. SBP drop is referring to the decrease in blood pressure often seen before death. Thus, the aim of this study was to examine whether SBP at time of diagnosis of dementia, mild cognitive impairment, or subjective cognitive decline was associated with years prior to death, and whether these associations were modified by diagnoses, age, and sex. Methods Participants were 2,236 patients from the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog), who died during follow-up (2009-2017) for whom we had valid blood pressure measurements. Mean age at diagnosis was 77.5 years (SD 8.3), and patients were followed for an average of 3.9 years (SD 2.2, maximum 10.5 years). The patients had subjective cognitive decline (95), mild cognitive impairment (573), dementia (1,401), or no diagnoses related to cognitive deficits (167). SBP as dependent variable was regressed against years prior to death. Results In men, SBP was 1.8 mmHg lower per year closer to death (p < .01), and this trend was linear without any acceleration. This association between years prior to death and SBP in men was not modified by age, year of diagnosis, or diagnosis. There was no such association in women. Conclusion SBP was significantly lower for those diagnosed close to death in men, but not in women. This association was not modified by either age or onset of diagnosis. Thus, the lowering of SBP is more related to closeness to death and sex than to dementia or age. The downward trend was linear all 10 years prior to death, with no acceleration closer to death.
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页数:7
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