Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity

被引：10

作者：

Madhavilatha, B. ^{[1
]}

Fatima, Narjis ^{[1
]}

Sabitha, Gowravaram ^{[1
]}

Reddy, B. V. Subba ^{[1
]}

Yadav, J. S. ^{[2
]}

Bhattacharjee, Debanjan ^{[3
]}

Jain, Nishant ^{[3
]}

机构：

[1] CSIR Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

[2] CSIR Indian Inst Chem Technol, Ctr Semiochem, Hyderabad 500007, Andhra Pradesh, India

[3] CSIR Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 08期

关键词：

Azides; Alkynes; 1,2,3-triazoles; Isoxazoles; Click chemistry; Cytotoxicity; COPPER(I)-CATALYZED SYNTHESIS; DERIVATIVES; INHIBITORS; ANTITUMOR; DISCOVERY; AGENTS;

D O I：

10.1007/s00044-017-1884-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel 1,2,3-triazole and isoxazole-linked pyrazole derivatives have been synthesized from pyrazole and triazole/isoxazole scaffolds. The synthesized congeners were evaluated for their anti-proliferative efficacy in four cancer cell lines (MCF7, HEPG2, IMR32, and HELA). Majority of the compounds demonstrated potent cytotoxic activities, among them 4k and 4l showed significant cytotoxicity in all the tested cell lines.

引用

页码：1753 / 1763

页数：11

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