Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions

被引:40
|
作者
Longley, Rhea J. [1 ,2 ,3 ]
White, Michael T. [1 ,4 ]
Takashima, Eizo [5 ]
Morita, Masayuki [5 ]
Kanoi, Bernard N. [5 ]
Suen, Connie S. N. Li Wai [1 ,2 ]
Betuela, Inoni [6 ]
Kuehn, Andrea [7 ]
Sripoorote, Piyarat [3 ]
Franca, Camila T. [1 ,2 ]
Siba, Peter [6 ]
Robinson, Leanne J. [1 ,2 ,6 ]
Lacerda, Marcus [8 ,9 ]
Sattabongkot, Jetsumon [3 ]
Tsuboi, Takafumi [5 ]
Mueller, Ivo [1 ,2 ,10 ]
机构
[1] Walter & Eliza Hall Inst Med Res, Populat Hlth & Immun Div, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia
[3] Mahidol Univ, Fac Trop Med, Mahidol Vivax Res Unit, Bangkok, Thailand
[4] Imperial Coll London, MRC, Ctr Outbreak Anal & Modelling, Dept Infect Dis Epidemiol, London, England
[5] Ehime Univ, Div Malaria Res, Proteosci Ctr, Matsuyama, Ehime, Japan
[6] PNG Inst Med Res, Vector Borne Dis Unit, Madang, Papua N Guinea
[7] Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Hosp Clin, Barcelona, Spain
[8] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil
[9] Inst Pesquisas Leonidas & Maria Deane, Manaus, Amazonas, Brazil
[10] Inst Pasteur, Dept Parasites & Insect Vectors, Malaria Parasites & Hosts Unit, Paris, France
来源
PLOS NEGLECTED TROPICAL DISEASES | 2017年 / 11卷 / 09期
基金
澳大利亚国家健康与医学研究理事会; 瑞士国家科学基金会;
关键词
HIGH-THROUGHPUT-MATERIALIZATION; MEROZOITE SURFACE PROTEIN-1; MALARIA; SYSTEM; FALCIPARUM; EPIDEMIOLOGY; INFECTIONS; IMMUNITY;
D O I
10.1371/journal.pntd.0005888
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2-3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.
引用
收藏
页数:15
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