Transduction of the discriminative stimulus effects of zolpidem by GABAA/α1 receptors

被引：13
|
作者：
Rowlett, JK [1 ]
Lelas, S [1 ]
Spealman, RD [1 ]
机构：
[1] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Southborough, MA 01772 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 406卷 / 01期
关键词：
zolpidem; benzodiazepine; drug discrimination;
D O I：
10.1016/S0014-2999(00)00669-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Zolpidem is an imidazopyridine with high affinity at gamma-aminobutyric acid(A) (GABA(A)) receptors expressing al subunits. In squirrel monkeys trained to discriminate a high dose of zolpidem(greater than or equal to 3.0 mg/kg) from saline, zolpidem and another GABA(A)/alpha 1 receptor-preferring agonist, zaleplon, substituted dose-dependently for zolpidem, whereas the non-selective agonists diazepam and triazolam were did not substitute at any dose tested. These findings offer the first evidence for a selective role of GABA(A)/alpha 1 receptors in the interoceptive effects of high doses of zolpidem. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：R9 / R10
页数：2
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