Drug therapy of experimental tuberculosis (TB): Improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs

被引：113
|
作者：
Nikonenko, Boris V.
Protopopova, Marina
Sarnala, Rowena
Einck, Leo
Nacy, Carol A.
机构：
[1] Sequella Inc, Rockville, MD 20850 USA
[2] Cent Res Inst TB, Moscow 107564, Russia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期
关键词：
D O I：
10.1128/AAC.01326-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log(10) lower in SQ109-containing regimens.
引用
收藏
页码：1563 / 1565
页数：3
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