Particle-beam weapon is a concept of directed energy weapons and used for attacking targets utilizing particle-beam with high energy. It is a scientific idea that attracts some attention and encourages of people to research in theory and experiment. Particle-Beam weapons can be classified into charged and neutral particle-beam weapons according the electrical property of particles. In this article, the basic principle is introduced firstly, including the acceleration, propagation, and interaction, which provides a theoretical support for design and construction of particle-beam weapon system. Besides, the target tracking system is focused on and discussed in detail, in which the estimation of trajectory is based on the model-filter process to adjust shoot direction in real-time. Actually, it is hard to be realized because of the tough technology limitation.