[1] Univ Edinburgh, Ctr Inflammat Res, Edinburgh EH25 9RG, Midlothian, Scotland
[2] Univ Edinburgh, Med Informat Ctr, Usher Inst, Edinburgh EH25 9RG, Midlothian, Scotland
[3] Univ Edinburgh, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland
[4] Univ Liverpool, Liverpool Clin Trials Ctr, Liverpool, Merseyside, England
[5] Univ Liverpool, Inst Infect Vet & Ecol Sci, Fac Hlth & Life Sci, Liverpool, Merseyside, England
[6] Leiden Univ, Dept Infect Dis, Leiden Univ Med Ctr, Leiden, Netherlands
[7] Imperial Coll London, Natl Heart & Lung Inst, London, England
[8] Alder Hey Childrens Hosp, Dept Resp Med, Liverpool, Merseyside, England