Correlation of calcium-independent phosphatidylcholine-specific phospholipase C with γ-GT in hepatoma cells

被引：0
|
作者：
Wu, XZ [1 ]
Lu, H [1 ]
机构：
[1] Shanghai Med Univ, Dept Biochem, Shanghai 200032, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 1998年 / 30卷 / 01期
关键词：
PC-PLC; gamma-GT; hepatoma;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We studied the activities of calcium-independent phosphatidylcholine-specific phospholipase C (PC-PLC) and the relationship between PC-PLC and gamma-GT in hepatoma cells. We noted that PC-PLC activity decreased significantly during hepatocarcinogenesis and the proliferation of CBRH-7919 cells, but increased significantly during differentiation. There was a close relationship between PC-PLC and gamma-GT activities. When CBRH-7919 cells were treated with exogenous PC-PLC, it took only 15 minutes for gamma-GT activity to decrease significantly and to the lowest level at 24 hours. However, gamma-GT activity in culture medium increased within 2 hours, then decreased afterward. We conclude that PC-PLC may regulate gamma-GT via certain pathways.
引用
收藏
页码：104 / 106
页数：3
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