Effect of echo time and T2-weighting on GRASE-based T1w/T2w ratio measurements at 3T

被引：7
|
作者：
Uddin, Md Nasir [1 ,2 ,3 ]
Figley, Teresa D. [1 ,2 ,3 ]
Figley, Chase R. [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Univ Manitoba, Dept Radiol, Winnipeg, MB, Canada
[2] Hlth Sci Ctr, Div Diagnost Imaging, Winnipeg, MB, Canada
[3] Kleysen Inst Adv Med, Neurosci Res Program, Winnipeg, MB, Canada
[4] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada
[5] Univ Manitoba, Biomed Engn Grad Program, Winnipeg, MB, Canada
[6] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD USA
来源：
MAGNETIC RESONANCE IMAGING | 2018年 / 51卷
基金：
加拿大自然科学与工程研究理事会; 美国国家卫生研究院; 加拿大健康研究院;
关键词：
Echo time; GRASE; Human brain; MRI; Myelin water imaging; T(1)w/T(2)w; T-2-weighting; MAGNETIC-RESONANCE RATIO; EARLY MULTIPLE-SCLEROSIS; HUMAN CEREBRAL-CORTEX; WHITE-MATTER; MYELIN CONTENT; HUMAN BRAIN; INTENSITY INHOMOGENEITY; T2-WEIGHTED MRI; IMAGING DATA; IMAGES;
D O I：
10.1016/j.mri.2018.04.012
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Tissue contrast can be enhanced by dividing T-1-weighted (T(1)w) images by T-2-weighted (T(2)w) images to map the so-called T(1)w/T(2)w ratio, which has become an increasingly popular technique for quantifying brain tissue changes associated with neurodevelopment, aging, and a variety of neurodegenerative diseases. However, although it is self-evident that T(1)w/T(2)w ratios increase with the amount of T-2-weighting in the T(2)w image which is determined by the echo time (TE), all else being equal - longer TEs also reduce the signal-to-noise ratio (SNR) of the T(2)w images, and it is not clear how these SNR characteristics affect the reliability of T(1)w/T(2)w measurements. Therefore, the current study systematically investigated how different amounts of T-2-weighting affected T(1)w/T(2)w measurements in order to determine whether there is an optimal amount of T-2-weighting. T(1)w images were acquired from 10 neurologically healthy adults using a 3D turbo field echo (TFE) sequence, and a series of T-2-weighted images were extracted from a multi-echo 3D combined gradient-and spin-echo (GRASE) sequence. Analyses of 12 anatomically defined brain regions revealed that both the mean and standard deviation of the T(1)w/T(2)w measurements increased exponentially with TE of the T(2)w images, and that T(2)w images with TE approximate to 120-160 ms yielded the most consistent/reproducible contrast between white matter ROIs and the whole brain T(1)w/T(2)w signal. Furthermore, comparisons between T(1)w/T(2)w measurements and multi-component T-2-relaxation myelin water fractions (MWFs) in the same brain regions revealed that T(2)w images with TE >= 160 ms drastically reduced the degree of correlation between T(1)w/T(2)w measurements and MWF. Overall, these findings suggest that: 1) there is a substantial trade-off between increased T(1)w/T(2)w contrast (based on longer TEs for the T(2)w images) and the reliability of quantitative T(1)w/T(2)w signals; and 2) the optimal TE for T(2)w GRASE scans is between 120 ms and 160 ms for calculating T(1)w/T(2)w ratios.
引用
收藏
页码：35 / 43
页数：9
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