Reversibility in heterogeneous flow immunosensing and related techniques. A brief overview.

In the development of many immunochemical techniques the reuse of the immunosorbent is one of the problems to be taken into account. The choice of an adequate desorbent agent which accomplishes an effective desorption without influencing the immunosorbent activity is the key to solving it. This is a review paper of the methods dealing with the problem of reversibility in immunochemical interactions and how the immunosurface life is modified, especially in fields as heterogeneous as flow immunoassays and immunoaffinity extraction and chromatography.