Extracellular vesicles: translational challenges and opportunities

被引：46
|
作者：
Clemmens, Hannah [1 ]
Lambert, Daniel W. [1 ,2 ]
机构：
[1] Univ Sheffield, Sch Clin Dent, Acad Unit Oral & Maxillofacial Pathol, Sheffield S10 2TA, S Yorkshire, England
[2] Univ Sheffield, Sheffield Inst Nucle Acids, Sheffield S10 2TA, S Yorkshire, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2018年 / 46卷
关键词：
NANOPARTICLE TRACKING ANALYSIS; MEDIATED TRANSFER; CANCER EXOSOMES; DRUG-DELIVERY; CELLS; MICROVESICLES; EXPRESSION; ASSOCIATION; BIOGENESIS; MICRORNAS;
D O I：
10.1042/BST20180112
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might be utilised as diagnostic and therapeutic tools. There remain, however, a number of challenges that must be overcome before EVs may be used routinely in the clinic. In this review we will discuss the translational potential of EVs and the current technologies available to isolate, purify and analyse EVs and their contents.
引用
收藏
页码：1073 / 1082
页数：10
相关论文
共 50 条
  • [1] Extracellular Vesicles and Hepatocellular Carcinoma: Opportunities and Challenges
    Wang, Juan
    Wang, Xiaoya
    Zhang, Xintong
    Shao, Tingting
    Luo, Yanmei
    Wang, Wei
    Han, Yunwei
    [J]. FRONTIERS IN ONCOLOGY, 2022, 12
  • [2] Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Diseases
    Tang, Tao-Tao
    Lv, Lin-Li
    Lan, Hui-Yao
    Liu, Bi-Cheng
    [J]. FRONTIERS IN PHYSIOLOGY, 2019, 10
  • [3] Extracellular vesicles in cancer: challenges and opportunities for clinical laboratories
    Gonzalez, Alvaro
    Lopez-Borrego, Silvia
    Sandua, Amaia
    Vales-Gomez, Mar
    Alegre, Estibaliz
    [J]. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2024, 61 (06) : 435 - 457
  • [4] Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges
    Lane, R. E.
    Korbie, D.
    Hill, M. M.
    Trau, M.
    [J]. CLINICAL AND TRANSLATIONAL MEDICINE, 2018, 7
  • [5] Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Fibrosis
    Tang, Tao-Tao
    Liu, Bi-Cheng
    [J]. RENAL FIBROSIS: MECHANISMS AND THERAPIES, 2019, 1165 : 693 - 709
  • [6] Challenges and Opportunities for Extracellular Vesicles in Clinical Oncology Therapy
    Lu, Shuya
    Cui, Qingfa
    Zheng, Huan
    Ma, Yuan
    Kang, Yanchun
    Tang, Ke
    [J]. BIOENGINEERING-BASEL, 2023, 10 (03):
  • [7] Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities
    Nagelkerke, Anika
    Ojansivu, Miina
    van der Koog, Luke
    Whittaker, Thomas E.
    Cunnane, Eoghan M.
    Silva, Andreia M.
    Dekker, Niek
    Stevens, Molly M.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2021, 175
  • [8] Extracellular vesicles in renal cell carcinoma: challenges and opportunities coexist
    Lu, Yukang
    Zhang, Mengting
    Zhou, Jiajun
    Liu, Xiulan
    Wang, Lanfeng
    Hu, Xinyi
    Mao, Yiping
    Gan, Rongfa
    Chen, Zhiping
    [J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [9] Extracellular vesicles as carriers of mRNA : Opportunities and challenges in diagnosis and treatment
    Kirian, Robert D.
    Steinman, Darby
    Jewell, Christopher M.
    Zierden, Hannah C.
    [J]. THERANOSTICS, 2024, 14 (05): : 2265 - 2289
  • [10] Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities
    Osorio-Querejeta, Inaki
    Alberro, Ainhoa
    Munoz-Culla, Maider
    Mager, Imre
    Otaegui, David
    [J]. FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 11
12345