Usefulness of mouse models to study the pathogenesis of Sjogren's syndrome

被引：32
|
作者：
Soyfool, M. S.
Steinfeld, S.
Delporte, C.
机构：
[1] Univ Libre Bruxelles, Lab Biol Chem & Nutr, B-1070 Brussels, Belgium
[2] Erasme Univ Hosp, Div Rheumatol, B-1070 Brussels, Belgium
来源：
ORAL DISEASES | 2007年 / 13卷 / 04期
关键词：
autoimmune exocrinopathy; mouse models; pathogenesis; Sjogren's syndrome;
D O I：
10.1111/j.1601-0825.2007.01376.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Sjogren's syndrome (SS) is an autoimmune disorder characterized by ocular and oral dryness as well as systemic manifestations. The immunopathogenesis of SS is complex with different intricate factors. Because of the delay in the appearance of symptoms and due to ethical issues it is very difficult to study the wide array of factors intervening in the pathogenesis of SS in human patients. To circumvent this problem, different animal models have been elaborated for studying the different subsets of the aspects of the physiopathology of this disease. In this review, we focus on the mouse models that have been established to deepen our insight into the immunopathogenesis of SS.
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收藏
页码：366 / 375
页数：10
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